Drug interactions
Indinavir + Ketamine
Severity: Moderate
Indinavir and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a potent CYP3A4 inhibitor and is expected to raise ketamine concentrations, particularly after oral dosing. This may prolong sedation, dissociation and cardiovascular stimulation.
What this interaction means in plain words
Indinavir and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated N-demethylation of ketamine by indinavir reduces ketamine clearance.
What to do
Titrate ketamine to effect and use lower doses. Monitor sedation, blood pressure and heart rate and extend observation after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Indinavir with Ketamine?
MediHelp rates the interaction as moderate. Indinavir and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a potent CYP3A4 inhibitor and is expected to raise ketamine concentrations, particularly after oral dosing. This may prolong sedation, dissociation and cardiovascular stimulation.
How serious is the interaction between Indinavir and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect and use lower doses. Monitor sedation, blood pressure and heart rate and extend observation after dosing.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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