Drug interactions
Indinavir + Lansoprazole
Severity: Moderate
Indinavir and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir needs gastric acid for optimal absorption, and lansoprazole can reduce its concentrations. This may compromise antiviral efficacy.
What this interaction means in plain words
Indinavir and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH decreases indinavir dissolution and absorption.
What to do
Avoid the combination when possible, or use an alternative acid suppressant or antiretroviral. If used together, monitor HIV viral load and consider indinavir exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Indinavir with Lansoprazole?
MediHelp rates the interaction as moderate. Indinavir and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir needs gastric acid for optimal absorption, and lansoprazole can reduce its concentrations. This may compromise antiviral efficacy.
How serious is the interaction between Indinavir and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, or use an alternative acid suppressant or antiretroviral. If used together, monitor HIV viral load and consider indinavir exposure.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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