Drug interactions
Indinavir + Metformin-sitagliptin
Severity: Moderate
Indinavir and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir and other protease inhibitors can induce insulin resistance and hyperglycemia, which may blunt the effect of metformin and sitagliptin.
What this interaction means in plain words
Indinavir and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors impair insulin signalling and glucose uptake, causing insulin resistance.
What to do
Monitor glucose and HbA1c after starting indinavir and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Indinavir with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Indinavir and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir and other protease inhibitors can induce insulin resistance and hyperglycemia, which may blunt the effect of metformin and sitagliptin.
How serious is the interaction between Indinavir and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting indinavir and adjust the antidiabetic regimen as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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