Drug interactions
Indinavir + Pitavastatin
Severity: Moderate
Indinavir and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir may inhibit OATP1B1, the main hepatic uptake route for pitavastatin. Higher statin levels can increase the risk of myopathy, although pitavastatin has little CYP metabolism.
What this interaction means in plain words
Indinavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits OATP1B1-mediated hepatic uptake of pitavastatin.
What to do
Monitor for muscle pain, weakness or dark urine, and check CK if symptoms develop. Use the lowest effective pitavastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Indinavir with Pitavastatin?
MediHelp rates the interaction as moderate. Indinavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir may inhibit OATP1B1, the main hepatic uptake route for pitavastatin. Higher statin levels can increase the risk of myopathy, although pitavastatin has little CYP metabolism.
How serious is the interaction between Indinavir and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness or dark urine, and check CK if symptoms develop. Use the lowest effective pitavastatin dose.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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