Drug interactions
Indinavir + Rabeprazole
Severity: Moderate
Indinavir and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir absorption depends on gastric acidity. Rabeprazole can lower indinavir exposure, risking reduced antiviral efficacy and resistance.
What this interaction means in plain words
Indinavir and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH reduces indinavir dissolution and absorption.
What to do
Avoid the combination if possible or choose another antiretroviral. If it is required, monitor HIV viral load closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Indinavir with Rabeprazole?
MediHelp rates the interaction as moderate. Indinavir and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir absorption depends on gastric acidity. Rabeprazole can lower indinavir exposure, risking reduced antiviral efficacy and resistance.
How serious is the interaction between Indinavir and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or choose another antiretroviral. If it is required, monitor HIV viral load closely.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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