Drug interactions
Indinavir + Ulipristal
Severity: Moderate
Indinavir and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise ulipristal levels. The safety consequences of higher exposure are not well defined.
What this interaction means in plain words
Indinavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4-mediated ulipristal metabolism.
What to do
Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on potential adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Indinavir with Ulipristal?
MediHelp rates the interaction as moderate. Indinavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise ulipristal levels. The safety consequences of higher exposure are not well defined.
How serious is the interaction between Indinavir and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on potential adverse effects.
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