Drug interactions
Indinavir + Venlafaxine
Severity: Moderate
Indinavir and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, a secondary pathway of venlafaxine metabolism, and may increase venlafaxine concentrations somewhat. Adverse effects such as nausea, hypertension and serotonergic symptoms may become more likely.
What this interaction means in plain words
Indinavir and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir reduces venlafaxine clearance.
What to do
Monitor blood pressure and tolerability, and lower the venlafaxine dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Indinavir with Venlafaxine?
MediHelp rates the interaction as moderate. Indinavir and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4, a secondary pathway of venlafaxine metabolism, and may increase venlafaxine concentrations somewhat. Adverse effects such as nausea, hypertension and serotonergic symptoms may become more likely.
How serious is the interaction between Indinavir and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and lower the venlafaxine dose if adverse effects develop.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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