Drug interactions
Indinavir + Zaleplon
Severity: Minor
Indinavir and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 inhibitor and may modestly increase zaleplon exposure. The effect is limited because zaleplon is cleared mainly by aldehyde oxidase, but added sedation can occur.
What this interaction means in plain words
Indinavir and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Indinavir inhibits CYP3A4, reducing the secondary oxidative metabolism of zaleplon.
What to do
Start with the lowest zaleplon dose and monitor for oversedation and psychomotor impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Indinavir with Zaleplon?
MediHelp rates the interaction as minor. Indinavir and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir is a CYP3A4 inhibitor and may modestly increase zaleplon exposure. The effect is limited because zaleplon is cleared mainly by aldehyde oxidase, but added sedation can occur.
How serious is the interaction between Indinavir and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest zaleplon dose and monitor for oversedation and psychomotor impairment.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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