Drug interactions
Infigratinib + Metronidazole
Severity: Minor
Infigratinib and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is metabolized mainly by CYP3A4. Metronidazole is at most a weak CYP3A4 inhibitor, so any increase in infigratinib exposure is probably small and unconfirmed.
What this interaction means in plain words
Infigratinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak CYP3A4 inhibition by metronidazole reducing infigratinib clearance.
What to do
No empirical dose change is needed. Monitor for infigratinib toxicity such as hyperphosphatemia and ocular effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Infigratinib with Metronidazole?
MediHelp rates the interaction as minor. Infigratinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Infigratinib is metabolized mainly by CYP3A4. Metronidazole is at most a weak CYP3A4 inhibitor, so any increase in infigratinib exposure is probably small and unconfirmed.
How serious is the interaction between Infigratinib and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for infigratinib toxicity such as hyperphosphatemia and ocular effects.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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