Drug interactions
Infigratinib + Rabeprazole
Severity: Major
Infigratinib and Rabeprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib absorption depends on an acidic gastric environment, and rabeprazole raises gastric pH for a prolonged period. This can reduce infigratinib exposure and may compromise its antitumor efficacy.
What this interaction means in plain words
Infigratinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Higher gastric pH reduces the pH-dependent solubility and absorption of oral infigratinib.
What to do
Avoid proton pump inhibitors during infigratinib therapy. If acid suppression is needed, use a locally acting antacid and separate it from infigratinib by the interval stated in the labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Infigratinib and Rabeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Infigratinib with Rabeprazole?
MediHelp rates the interaction as major. Infigratinib and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infigratinib absorption depends on an acidic gastric environment, and rabeprazole raises gastric pH for a prolonged period. This can reduce infigratinib exposure and may compromise its antitumor efficacy.
How serious is the interaction between Infigratinib and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid proton pump inhibitors during infigratinib therapy. If acid suppression is needed, use a locally acting antacid and separate it from infigratinib by the interval stated in the labeling.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
