Drug interactions
Influenza a vaccine + Methotrexate
Severity: Moderate
Influenza a vaccine and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression with methotrexate may reduce the immune response to the inactivated H5N1 influenza vaccine. Protection may be lower than in immunocompetent people, though vaccination remains worthwhile.
What this interaction means in plain words
Influenza a vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate impairs lymphocyte proliferation and antibody production.
What to do
Give the vaccine when indicated and do not delay it unnecessarily. Continue other preventive measures, as protection may be incomplete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Influenza a vaccine with Methotrexate?
MediHelp rates the interaction as moderate. Influenza a vaccine and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression with methotrexate may reduce the immune response to the inactivated H5N1 influenza vaccine. Protection may be lower than in immunocompetent people, though vaccination remains worthwhile.
How serious is the interaction between Influenza a vaccine and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine when indicated and do not delay it unnecessarily. Continue other preventive measures, as protection may be incomplete.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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