Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Mercaptopurine
Severity: Minor
Influenza virus vaccine quadrivalent adjuvanted and Mercaptopurine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mercaptopurine may blunt the antibody response to inactivated influenza vaccine. The vaccine is not live and remains safe to give.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Mercaptopurine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression reduces vaccine-induced antibody production.
What to do
Give the annual inactivated influenza vaccine as recommended; do not withhold it because of mercaptopurine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Mercaptopurine?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent adjuvanted and Mercaptopurine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mercaptopurine may blunt the antibody response to inactivated influenza vaccine. The vaccine is not live and remains safe to give.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Mercaptopurine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the annual inactivated influenza vaccine as recommended; do not withhold it because of mercaptopurine.
What other medicines interact with Mercaptopurine?
MediHelp also lists interactions of Mercaptopurine with, for example, Adenovirus types 4 and 7 live, Azathioprine, Bcg vaccine live. The full list is on the Mercaptopurine page.
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