Drug interactions
Influenza virus vaccine quadrivalent + Methotrexate
Severity: Moderate
Influenza virus vaccine quadrivalent and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methotrexate can lower the antibody response to inactivated influenza vaccine. Patients are still advised to be vaccinated because influenza carries substantial risk in immunosuppressed people.
What this interaction means in plain words
Influenza virus vaccine quadrivalent and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methotrexate suppresses lymphocyte proliferation and humoral responses.
What to do
Vaccinate annually. In stable rheumatic disease, consider holding methotrexate for about two weeks after vaccination if disease control allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent with Methotrexate?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate can lower the antibody response to inactivated influenza vaccine. Patients are still advised to be vaccinated because influenza carries substantial risk in immunosuppressed people.
How serious is the interaction between Influenza virus vaccine quadrivalent and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate annually. In stable rheumatic disease, consider holding methotrexate for about two weeks after vaccination if disease control allows.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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