Drug interactions
Insulin aspart + Octreotide
Severity: Moderate
Insulin aspart and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone secretion, which can unpredictably cause either hypoglycemia or hyperglycemia in patients on insulin. Insulin requirements may change, especially when starting or stopping octreotide.
What this interaction means in plain words
Insulin aspart and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Octreotide alters counter-regulatory hormone and endogenous insulin secretion, changing glycemic control and insulin requirements.
What to do
Monitor blood glucose frequently when starting, changing or stopping octreotide, and adjust insulin doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Octreotide?
MediHelp rates the interaction as moderate. Insulin aspart and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone secretion, which can unpredictably cause either hypoglycemia or hyperglycemia in patients on insulin. Insulin requirements may change, especially when starting or stopping octreotide.
How serious is the interaction between Insulin aspart and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting, changing or stopping octreotide, and adjust insulin doses accordingly.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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