Drug interactions
Insulin aspart + Olanzapine
Severity: Moderate
Insulin aspart and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can raise blood glucose and cause insulin resistance, which may counteract the glucose-lowering effect of insulin aspart. Patients may need higher insulin doses and glycemic control can become less predictable.
What this interaction means in plain words
Insulin aspart and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine causes weight gain, insulin resistance and impaired glucose regulation, opposing the pharmacodynamic effect of insulin.
What to do
Monitor blood glucose more frequently when olanzapine is started, changed or stopped, and adjust the insulin dose as needed. Check HbA1c and weight periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Olanzapine?
MediHelp rates the interaction as moderate. Insulin aspart and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can raise blood glucose and cause insulin resistance, which may counteract the glucose-lowering effect of insulin aspart. Patients may need higher insulin doses and glycemic control can become less predictable.
How serious is the interaction between Insulin aspart and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when olanzapine is started, changed or stopped, and adjust the insulin dose as needed. Check HbA1c and weight periodically.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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