Drug interactions
Insulin aspart + Sacubitril / valsartan
Severity: Moderate
Insulin aspart and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and occasionally increase the glucose-lowering effect of insulin. Hypoglycemia is possible, particularly when treatment starts.
What this interaction means in plain words
Insulin aspart and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Angiotensin II blockade is thought to improve insulin sensitivity and glucose uptake; the mechanism is not fully established.
What to do
Monitor blood glucose after starting or changing sacubitril/valsartan. Lower the insulin aspart dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Insulin aspart and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity and occasionally increase the glucose-lowering effect of insulin. Hypoglycemia is possible, particularly when treatment starts.
How serious is the interaction between Insulin aspart and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing sacubitril/valsartan. Lower the insulin aspart dose if hypoglycemia develops.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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