Drug interactions
Insulin aspart + Somatropin
Severity: Moderate
Insulin aspart and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin can reduce insulin sensitivity, so patients on insulin aspart may need larger doses to maintain glycemic control. Needs can change again when growth hormone is stopped or reduced.
What this interaction means in plain words
Insulin aspart and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and increases hepatic glucose output and lipolysis.
What to do
Monitor blood glucose frequently when starting or changing the somatropin dose. Adjust the insulin dose, and reduce it if somatropin is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Somatropin?
MediHelp rates the interaction as moderate. Insulin aspart and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin can reduce insulin sensitivity, so patients on insulin aspart may need larger doses to maintain glycemic control. Needs can change again when growth hormone is stopped or reduced.
How serious is the interaction between Insulin aspart and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting or changing the somatropin dose. Adjust the insulin dose, and reduce it if somatropin is withdrawn.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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