Drug interactions
Insulin aspart + Sulfisoxazole
Severity: Moderate
Insulin aspart and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can lower blood glucose and may add to the effect of insulin, occasionally causing hypoglycemia. Risk is higher in renal impairment or poor nutrition.
What this interaction means in plain words
Insulin aspart and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may stimulate insulin secretion in a sulfonylurea-like manner; the effect is additive with exogenous insulin.
What to do
Monitor blood glucose during sulfisoxazole therapy, especially in renal impairment. Reduce the insulin aspart dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Sulfisoxazole?
MediHelp rates the interaction as moderate. Insulin aspart and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics can lower blood glucose and may add to the effect of insulin, occasionally causing hypoglycemia. Risk is higher in renal impairment or poor nutrition.
How serious is the interaction between Insulin aspart and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfisoxazole therapy, especially in renal impairment. Reduce the insulin aspart dose if hypoglycemia occurs.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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