Drug interactions
Insulin aspart-insulin aspart protamine + Lithium
Severity: Minor
Insulin aspart-insulin aspart protamine and Lithium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can alter glucose tolerance, producing either hypoglycemia or hyperglycemia in different patients. This may make insulin requirements less predictable.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Lithium may affect insulin secretion and carbohydrate metabolism; the exact mechanism is not well established.
What to do
Monitor blood glucose when lithium is started, stopped or changed. Adjust the insulin dose according to readings.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Lithium?
MediHelp rates the interaction as minor. Insulin aspart-insulin aspart protamine and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lithium can alter glucose tolerance, producing either hypoglycemia or hyperglycemia in different patients. This may make insulin requirements less predictable.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Lithium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lithium is started, stopped or changed. Adjust the insulin dose according to readings.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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