Drug interactions
Insulin aspart-insulin aspart protamine + Metoclopramide intranasal
Severity: Moderate
Insulin aspart-insulin aspart protamine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying, which may alter the timing of nutrient absorption relative to insulin action. This can cause unpredictable glucose swings, including postprandial hyperglycemia or hypoglycemia.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prokinetic effect changes the rate of nutrient delivery to the intestine, creating a mismatch with insulin action.
What to do
Monitor blood glucose, especially around meals, and adjust insulin dose or timing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide speeds gastric emptying, which may alter the timing of nutrient absorption relative to insulin action. This can cause unpredictable glucose swings, including postprandial hyperglycemia or hypoglycemia.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially around meals, and adjust insulin dose or timing as needed.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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