Drug interactions
Insulin aspart-insulin aspart protamine + Octreotide
Severity: Moderate
Insulin aspart-insulin aspart protamine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone secretion, so glucose control can shift unpredictably in insulin-treated patients. Both hypoglycemia and hyperglycemia have occurred.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Somatostatin analog inhibits secretion of insulin and counter-regulatory hormones such as glucagon and growth hormone.
What to do
Monitor glucose frequently when starting, changing or stopping octreotide. Adjust insulin doses according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Octreotide
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Octreotide?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone secretion, so glucose control can shift unpredictably in insulin-treated patients. Both hypoglycemia and hyperglycemia have occurred.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently when starting, changing or stopping octreotide. Adjust insulin doses according to readings.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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