Drug interactions
Insulin aspart-insulin aspart protamine + Sacubitril / valsartan
Severity: Minor
Insulin aspart-insulin aspart protamine and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, with a possible increase in hypoglycemia. The effect is usually modest.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Angiotensin receptor blockade may enhance insulin sensitivity, and the exact mechanism is not firmly established.
What to do
Monitor blood glucose when starting therapy and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Insulin aspart-insulin aspart protamine and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, with a possible increase in hypoglycemia. The effect is usually modest.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting therapy and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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