Drug interactions
Insulin aspart-insulin aspart protamine + Salsalate
Severity: Moderate
Insulin aspart-insulin aspart protamine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, which is hydrolyzed to salicylic acid, can lower blood glucose and enhance insulin effect at higher doses, raising hypoglycemia risk.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate increases insulin secretion and glucose utilization, additive to insulin.
What to do
Monitor glucose more often when salsalate is started or titrated and reduce insulin if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Salsalate?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, which is hydrolyzed to salicylic acid, can lower blood glucose and enhance insulin effect at higher doses, raising hypoglycemia risk.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often when salsalate is started or titrated and reduce insulin if hypoglycemia occurs.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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