Drug interactions
Insulin aspart-insulin aspart protamine + Sulfisoxazole
Severity: Moderate
Insulin aspart-insulin aspart protamine and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can enhance the glucose-lowering effect of insulin and have occasionally been linked to hypoglycemia in diabetic patients. The risk is greater in renal impairment or with poor oral intake.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may stimulate insulin secretion and possibly add to glucose lowering; the exact mechanism with insulin is not firmly established.
What to do
Monitor blood glucose more frequently when starting or stopping sulfisoxazole. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Sulfisoxazole?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics can enhance the glucose-lowering effect of insulin and have occasionally been linked to hypoglycemia in diabetic patients. The risk is greater in renal impairment or with poor oral intake.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping sulfisoxazole. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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