Drug interactions
Insulin aspart protamine / insulin aspart + Olmesartan
Severity: Minor
Insulin aspart protamine / insulin aspart and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose lowering of insulin, raising the risk of hypoglycemia. The effect is generally modest, but can be relevant at the start of ARB therapy.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible improvement in insulin sensitivity from angiotensin II receptor blockade producing additive glucose lowering.
What to do
Monitor blood glucose more frequently when olmesartan is started or adjusted. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Olmesartan?
MediHelp rates the interaction as minor. Insulin aspart protamine / insulin aspart and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may enhance insulin sensitivity and increase the glucose lowering of insulin, raising the risk of hypoglycemia. The effect is generally modest, but can be relevant at the start of ARB therapy.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when olmesartan is started or adjusted. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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