Drug interactions
Insulin aspart protamine / insulin aspart + Somatropin
Severity: Moderate
Insulin aspart protamine / insulin aspart and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin reduces insulin sensitivity, so patients on insulin may need higher doses to maintain glycemic control. Hyperglycemia may appear after growth hormone is started or the dose is increased.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Growth hormone induces insulin resistance, opposing the glucose-lowering action of insulin.
What to do
Monitor blood glucose frequently after starting or changing somatropin, and titrate the insulin dose upward as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Somatropin?
MediHelp rates the interaction as moderate. Insulin aspart protamine / insulin aspart and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin reduces insulin sensitivity, so patients on insulin may need higher doses to maintain glycemic control. Hyperglycemia may appear after growth hormone is started or the dose is increased.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently after starting or changing somatropin, and titrate the insulin dose upward as needed.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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