Drug interactions
Insulin degludec / insulin aspart + Octreotide
Severity: Moderate
Insulin degludec / insulin aspart and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide alters glucose homeostasis by suppressing insulin, glucagon and growth hormone secretion, so insulin requirements can change unpredictably. Hypoglycemia or hyperglycemia may occur, particularly after starting or changing octreotide.
What this interaction means in plain words
Insulin degludec / insulin aspart and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Octreotide suppresses endogenous insulin, glucagon and growth hormone secretion, producing variable pharmacodynamic effects on glucose.
What to do
Monitor blood glucose more frequently when starting, adjusting or stopping octreotide. Adjust insulin doses according to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Octreotide?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide alters glucose homeostasis by suppressing insulin, glucagon and growth hormone secretion, so insulin requirements can change unpredictably. Hypoglycemia or hyperglycemia may occur, particularly after starting or changing octreotide.
How serious is the interaction between Insulin degludec / insulin aspart and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, adjusting or stopping octreotide. Adjust insulin doses according to glucose readings.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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