Drug interactions
Insulin degludec / insulin aspart + Perindopril
Severity: Moderate
Insulin degludec / insulin aspart and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of insulin. This can lead to more frequent or unexpected hypoglycemia, especially after starting the ACE inhibitor or in patients with renal impairment.
What this interaction means in plain words
Insulin degludec / insulin aspart and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition enhances insulin sensitivity (possibly via increased bradykinin), producing additive pharmacodynamic lowering of blood glucose.
What to do
Monitor blood glucose more frequently when perindopril is started or the dose is changed. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Perindopril?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of insulin. This can lead to more frequent or unexpected hypoglycemia, especially after starting the ACE inhibitor or in patients with renal impairment.
How serious is the interaction between Insulin degludec / insulin aspart and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when perindopril is started or the dose is changed. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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