Drug interactions
Insulin detemir + Olanzapine
Severity: Moderate
Insulin detemir and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can raise glucose and cause insulin resistance, which may blunt the effect of insulin detemir. Glycemic control may deteriorate and insulin requirements may increase.
What this interaction means in plain words
Insulin detemir and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine induces insulin resistance and weight gain, opposing insulin action.
What to do
Monitor glucose closely after starting or changing olanzapine and adjust insulin detemir dose accordingly. Review HbA1c and weight regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Insulin detemir
Frequently asked questions
Can I take Insulin detemir with Olanzapine?
MediHelp rates the interaction as moderate. Insulin detemir and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can raise glucose and cause insulin resistance, which may blunt the effect of insulin detemir. Glycemic control may deteriorate and insulin requirements may increase.
How serious is the interaction between Insulin detemir and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely after starting or changing olanzapine and adjust insulin detemir dose accordingly. Review HbA1c and weight regularly.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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