Drug interactions
Insulin detemir + Sacubitril / valsartan
Severity: Moderate
Insulin detemir and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockade and neprilysin inhibition may improve insulin sensitivity, potentially increasing the glucose-lowering effect of insulin. Hypoglycemia has been reported with sacubitril/valsartan in diabetic patients.
What this interaction means in plain words
Insulin detemir and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enhanced insulin sensitivity from RAAS blockade and increased natriuretic peptide activity produces additive glucose lowering.
What to do
Monitor blood glucose when starting sacubitril/valsartan. Reduce insulin detemir dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Frequently asked questions
Can I take Insulin detemir with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Insulin detemir and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockade and neprilysin inhibition may improve insulin sensitivity, potentially increasing the glucose-lowering effect of insulin. Hypoglycemia has been reported with sacubitril/valsartan in diabetic patients.
How serious is the interaction between Insulin detemir and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting sacubitril/valsartan. Reduce insulin detemir dose if hypoglycemia develops.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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