Drug interactions
Insulin detemir + Saquinavir
Severity: Moderate
Insulin detemir and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir may cause insulin resistance and hyperglycemia, which can reduce the effect of insulin detemir. Insulin requirements may increase.
What this interaction means in plain words
Insulin detemir and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors induce peripheral insulin resistance and impaired glucose uptake.
What to do
Monitor glucose regularly after starting saquinavir and increase insulin detemir as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin detemir and Saquinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin detemir
Frequently asked questions
Can I take Insulin detemir with Saquinavir?
MediHelp rates the interaction as moderate. Insulin detemir and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir may cause insulin resistance and hyperglycemia, which can reduce the effect of insulin detemir. Insulin requirements may increase.
How serious is the interaction between Insulin detemir and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose regularly after starting saquinavir and increase insulin detemir as needed.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
