Drug interactions
Insulin detemir + Xipamide
Severity: Moderate
Insulin detemir and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide, a thiazide-like diuretic, can raise blood glucose and worsen glycemic control, reducing the effect of insulin. It does not meaningfully increase insulin clearance.
What this interaction means in plain words
Insulin detemir and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and insulin resistance impair glucose tolerance.
What to do
Monitor blood glucose and serum potassium after starting xipamide. Increase the insulin dose if needed and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Frequently asked questions
Can I take Insulin detemir with Xipamide?
MediHelp rates the interaction as moderate. Insulin detemir and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide, a thiazide-like diuretic, can raise blood glucose and worsen glycemic control, reducing the effect of insulin. It does not meaningfully increase insulin clearance.
How serious is the interaction between Insulin detemir and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting xipamide. Increase the insulin dose if needed and correct hypokalemia.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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