Drug interactions
Insulin lispro + Sacubitril / valsartan
Severity: Moderate
Insulin lispro and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and sacubitril/valsartan has been associated with lower glucose and HbA1c. Insulin-treated patients may experience hypoglycemia.
What this interaction means in plain words
Insulin lispro and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Improved insulin sensitivity from RAAS blockade and neprilysin inhibition adds to the effect of insulin.
What to do
Monitor glucose when starting sacubitril/valsartan and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Frequently asked questions
Can I take Insulin lispro with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Insulin lispro and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may improve insulin sensitivity and sacubitril/valsartan has been associated with lower glucose and HbA1c. Insulin-treated patients may experience hypoglycemia.
How serious is the interaction between Insulin lispro and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting sacubitril/valsartan and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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