Drug interactions
Insulin lispro + Salsalate
Severity: Moderate
Insulin lispro and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, and at anti-inflammatory doses it can lower blood glucose. Combined with insulin lispro it may cause hypoglycemia.
What this interaction means in plain words
Insulin lispro and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate enhances insulin sensitivity and secretion, adding to the effect of insulin.
What to do
Monitor blood glucose more frequently when salsalate is started, stopped or changed in dose. Reduce the insulin lispro dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Frequently asked questions
Can I take Insulin lispro with Salsalate?
MediHelp rates the interaction as moderate. Insulin lispro and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylic acid, and at anti-inflammatory doses it can lower blood glucose. Combined with insulin lispro it may cause hypoglycemia.
How serious is the interaction between Insulin lispro and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when salsalate is started, stopped or changed in dose. Reduce the insulin lispro dose if hypoglycemia occurs.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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