Drug interactions
Insulin lispro protamine / insulin lispro + Telmisartan
Severity: Moderate
Insulin lispro protamine / insulin lispro and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan may improve insulin sensitivity and potentiate the glucose-lowering effect of lispro insulin mixtures. This may cause hypoglycemia, especially after the ARB is first started.
What this interaction means in plain words
Insulin lispro protamine / insulin lispro and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect, probably through improved insulin sensitivity with ARBs.
What to do
Monitor glucose more frequently when starting or changing telmisartan. Decrease the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Insulin lispro protamine / insulin lispro with Telmisartan?
MediHelp rates the interaction as moderate. Insulin lispro protamine / insulin lispro and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telmisartan may improve insulin sensitivity and potentiate the glucose-lowering effect of lispro insulin mixtures. This may cause hypoglycemia, especially after the ARB is first started.
How serious is the interaction between Insulin lispro protamine / insulin lispro and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more frequently when starting or changing telmisartan. Decrease the insulin dose if hypoglycemia occurs.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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