Drug interactions
Insulin neutral human + Olanzapine
Severity: Moderate
Insulin neutral human and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine commonly causes weight gain, insulin resistance and hyperglycemia, which can reduce insulin effectiveness and raise dose requirements. Diabetic ketoacidosis has been reported with its use.
What this interaction means in plain words
Insulin neutral human and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine induces insulin resistance and impairs beta-cell function, opposing insulin action.
What to do
Monitor glucose and HbA1c regularly after starting olanzapine and increase insulin as required. Consider a less diabetogenic antipsychotic if control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Olanzapine
Frequently asked questions
Can I take Insulin neutral human with Olanzapine?
MediHelp rates the interaction as moderate. Insulin neutral human and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine commonly causes weight gain, insulin resistance and hyperglycemia, which can reduce insulin effectiveness and raise dose requirements. Diabetic ketoacidosis has been reported with its use.
How serious is the interaction between Insulin neutral human and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly after starting olanzapine and increase insulin as required. Consider a less diabetogenic antipsychotic if control is poor.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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