Drug interactions
Insulin neutral human + Somatropin
Severity: Moderate
Insulin neutral human and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces peripheral insulin sensitivity and can raise blood glucose, particularly at higher doses. Patients on insulin may therefore need larger insulin doses after somatropin is started, and glucose control may worsen.
What this interaction means in plain words
Insulin neutral human and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and increases hepatic glucose output and lipolysis.
What to do
Monitor blood glucose more frequently when starting or adjusting somatropin and titrate the insulin dose as needed. Reassess insulin requirements if somatropin is reduced or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Insulin neutral human with Somatropin?
MediHelp rates the interaction as moderate. Insulin neutral human and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces peripheral insulin sensitivity and can raise blood glucose, particularly at higher doses. Patients on insulin may therefore need larger insulin doses after somatropin is started, and glucose control may worsen.
How serious is the interaction between Insulin neutral human and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or adjusting somatropin and titrate the insulin dose as needed. Reassess insulin requirements if somatropin is reduced or stopped.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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