Drug interactions
Insulin neutral human-insulin isophane protamine human + Lithium
Severity: Minor
Insulin neutral human-insulin isophane protamine human and Lithium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can alter glucose metabolism, causing either hypoglycemia or hyperglycemia, which can make insulin requirements less predictable.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Lithium has insulin-like effects on glucose uptake and can also impair glucose tolerance; the net mechanism is variable and not well defined.
What to do
Monitor glucose more often after starting or changing lithium and adjust insulin to the observed response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Lithium?
MediHelp rates the interaction as minor. Insulin neutral human-insulin isophane protamine human and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lithium can alter glucose metabolism, causing either hypoglycemia or hyperglycemia, which can make insulin requirements less predictable.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Lithium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often after starting or changing lithium and adjust insulin to the observed response.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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