Drug interactions
Insulin neutral human-insulin isophane protamine human + Metformin
Severity: Minor
Insulin neutral human-insulin isophane protamine human and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin combined with insulin is a common regimen, but it can increase the risk of hypoglycemia. Insulin requirements often fall once metformin is added.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Metformin belongs to Endocrine.
Why it happens
Complementary glucose lowering: metformin reduces hepatic glucose output and improves insulin sensitivity, adding to insulin action.
What to do
Monitor glucose when starting metformin and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Metformin
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Metformin?
MediHelp rates the interaction as minor. Insulin neutral human-insulin isophane protamine human and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin combined with insulin is a common regimen, but it can increase the risk of hypoglycemia. Insulin requirements often fall once metformin is added.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting metformin and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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