Drug interactions
Insulin neutral human-insulin isophane protamine human + Metoclopramide intranasal
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying, which may alter the timing of nutrient absorption relative to insulin action. This can cause unpredictable glucose swings, including postprandial hyperglycemia or hypoglycemia.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prokinetic effect changes the rate of nutrient delivery to the intestine, creating a mismatch with insulin action.
What to do
Monitor blood glucose, especially around meals, and adjust insulin dose or timing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide speeds gastric emptying, which may alter the timing of nutrient absorption relative to insulin action. This can cause unpredictable glucose swings, including postprandial hyperglycemia or hypoglycemia.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially around meals, and adjust insulin dose or timing as needed.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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