Drug interactions
Insulin neutral human-insulin isophane protamine human + Octreotide
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone, so glucose control can change unpredictably in insulin-treated patients. Hypoglycemia or hyperglycemia may occur and insulin needs often change.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Somatostatin analog inhibits secretion of insulin, glucagon and counter-regulatory hormones, altering glucose homeostasis.
What to do
Monitor glucose frequently when starting, changing or stopping octreotide and adjust insulin accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Octreotide
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Octreotide?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone, so glucose control can change unpredictably in insulin-treated patients. Hypoglycemia or hyperglycemia may occur and insulin needs often change.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently when starting, changing or stopping octreotide and adjust insulin accordingly.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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