Drug interactions
Insulin neutral human-insulin isophane protamine human + Sacubitril / valsartan
Severity: Minor
Insulin neutral human-insulin isophane protamine human and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, with a possible increase in hypoglycemia. The effect is usually modest.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Angiotensin receptor blockade may enhance insulin sensitivity, and the exact mechanism is not firmly established.
What to do
Monitor blood glucose when starting therapy and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin neutral human-insulin isophane protamine human and Sacubitril / valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Insulin neutral human-insulin isophane protamine human and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan may improve insulin sensitivity and enhance the glucose-lowering effect of insulin, with a possible increase in hypoglycemia. The effect is usually modest.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting therapy and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
