Drug interactions
Insulin neutral human-insulin isophane protamine human + Salsalate
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, which at anti-inflammatory doses can lower blood glucose and potentiate insulin, leading to hypoglycemia.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate enhances insulin sensitivity and secretion, adding to insulin's glucose-lowering effect.
What to do
Monitor blood glucose more frequently when starting or adjusting salsalate and lower the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Salsalate?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylic acid, which at anti-inflammatory doses can lower blood glucose and potentiate insulin, leading to hypoglycemia.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or adjusting salsalate and lower the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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