Drug interactions
Insulin neutral human-insulin isophane protamine human + Somatropin
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone induces insulin resistance and can raise blood glucose, reducing the effect of insulin. Insulin requirements may increase, especially at higher somatropin doses.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone reduces peripheral insulin sensitivity and increases hepatic glucose output and lipolysis.
What to do
Monitor blood glucose more often when somatropin is started or its dose is changed and adjust insulin as needed. Reduce insulin if somatropin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin neutral human-insulin isophane protamine human and Somatropin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Somatropin?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone induces insulin resistance and can raise blood glucose, reducing the effect of insulin. Insulin requirements may increase, especially at higher somatropin doses.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when somatropin is started or its dose is changed and adjust insulin as needed. Reduce insulin if somatropin is stopped.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
