Drug interactions
Insulin neutral human-insulin isophane protamine human + Sulfadiazine
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can potentiate glucose lowering and have been associated with hypoglycemia, particularly in patients with renal impairment. Used with insulin, this may increase the risk of low blood glucose.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may stimulate insulin secretion and the exact mechanism with insulin is not well established.
What to do
Monitor blood glucose during sulfadiazine therapy and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Sulfadiazine?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics can potentiate glucose lowering and have been associated with hypoglycemia, particularly in patients with renal impairment. Used with insulin, this may increase the risk of low blood glucose.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfadiazine therapy and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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