Drug interactions
Interferon beta 1b + Lisocabtagene maraleucel
Severity: Major
Interferon beta 1b and Lisocabtagene maraleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisocabtagene maraleucel is a CAR-T therapy associated with prolonged cytopenias and increased susceptibility to infection. Interferon beta may contribute further immune modulation and blood count suppression. Clinical data on this combination are lacking.
What this interaction means in plain words
Interferon beta 1b and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Interferon beta 1b belongs to Central Nervous System; Lisocabtagene maraleucel belongs to Oncology.
Why it happens
Additive immunosuppressive and myelosuppressive effects; the impact of interferon on CAR-T expansion is not established.
What to do
Avoid interferon beta around CAR-T therapy and choose an alternative where possible. If coadministered, monitor blood counts and infection signs closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Interferon beta 1b
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Interferon beta 1b with Lisocabtagene maraleucel?
MediHelp rates the interaction as major. Interferon beta 1b and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisocabtagene maraleucel is a CAR-T therapy associated with prolonged cytopenias and increased susceptibility to infection. Interferon beta may contribute further immune modulation and blood count suppression. Clinical data on this combination are lacking.
How serious is the interaction between Interferon beta 1b and Lisocabtagene maraleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid interferon beta around CAR-T therapy and choose an alternative where possible. If coadministered, monitor blood counts and infection signs closely.
What other medicines interact with Interferon beta 1b?
MediHelp also lists interactions of Interferon beta 1b with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Ciltacabtagene autoleucel. The full list is on the Interferon beta 1b page.
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