Drug interactions
Iobenguane i + Methyldopa
Severity: Major
Iobenguane i and Methyldopa: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methyldopa interferes with catecholamine handling and may reduce uptake of iobenguane into target cells. This can lower its diagnostic or therapeutic efficacy.
What this interaction means in plain words
Iobenguane i and Methyldopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Depletion or false-transmitter replacement of catecholamine stores and altered neuronal uptake reduce iobenguane accumulation.
What to do
Discontinue methyldopa for at least five half-lives before iobenguane dosimetry or therapy and do not resume until at least 7 days after each dose, using an alternative antihypertensive meanwhile.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
- Adrenaline-articaine + Methyldopa Moderate
Frequently asked questions
Can I take Iobenguane i with Methyldopa?
MediHelp rates the interaction as major. Iobenguane i and Methyldopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methyldopa interferes with catecholamine handling and may reduce uptake of iobenguane into target cells. This can lower its diagnostic or therapeutic efficacy.
How serious is the interaction between Iobenguane i and Methyldopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue methyldopa for at least five half-lives before iobenguane dosimetry or therapy and do not resume until at least 7 days after each dose, using an alternative antihypertensive meanwhile.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Lofexidine, Pexidartinib. The full list is on the Methyldopa page.
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