Drug interactions
Ioversol + Methotrexate
Severity: Moderate
Ioversol and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause acute kidney injury, which can slow methotrexate elimination and cause toxicity. This matters most with high-dose methotrexate or in patients who already have impaired renal function.
What this interaction means in plain words
Ioversol and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Contrast-induced renal impairment reduces renal clearance of methotrexate.
What to do
Ensure adequate hydration and check renal function before and after contrast. With high-dose methotrexate, delay the contrast study or monitor methotrexate levels and blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Ioversol with Methotrexate?
MediHelp rates the interaction as moderate. Ioversol and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast media can cause acute kidney injury, which can slow methotrexate elimination and cause toxicity. This matters most with high-dose methotrexate or in patients who already have impaired renal function.
How serious is the interaction between Ioversol and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check renal function before and after contrast. With high-dose methotrexate, delay the contrast study or monitor methotrexate levels and blood counts.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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