Drug interactions
Irinotecan liposomal + Isoniazid
Severity: Moderate
Irinotecan liposomal and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is converted to active SN-38 and also inactivated through CYP3A4 pathways. Altered CYP3A4 activity can change exposure to the active metabolite and thus the severity of neutropenia and diarrhea. Isoniazid is a weak inhibitor, so any effect is likely small and unproven.
What this interaction means in plain words
Irinotecan liposomal and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible modest inhibition of CYP3A4-mediated irinotecan metabolism by isoniazid; the clinical effect is not well established.
What to do
Monitor blood counts and diarrhea during treatment, and apply the usual irinotecan dose-modification rules for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Irinotecan liposomal with Isoniazid?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan is converted to active SN-38 and also inactivated through CYP3A4 pathways. Altered CYP3A4 activity can change exposure to the active metabolite and thus the severity of neutropenia and diarrhea. Isoniazid is a weak inhibitor, so any effect is likely small and unproven.
How serious is the interaction between Irinotecan liposomal and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea during treatment, and apply the usual irinotecan dose-modification rules for toxicity.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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