Drug interactions
Isoniazid + Isradipine
Severity: Minor
Isoniazid and Isradipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is extensively metabolized by CYP3A4, so inhibitors can raise levels and cause hypotension and edema. Isoniazid is a weak inhibitor, so the effect is likely small.
What this interaction means in plain words
Isoniazid and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by isoniazid may modestly reduce isradipine clearance.
What to do
Monitor blood pressure and heart rate when starting isoniazid. Reduce the isradipine dose if hypotension or marked edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Isoniazid with Isradipine?
MediHelp rates the interaction as minor. Isoniazid and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isradipine is extensively metabolized by CYP3A4, so inhibitors can raise levels and cause hypotension and edema. Isoniazid is a weak inhibitor, so the effect is likely small.
How serious is the interaction between Isoniazid and Isradipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting isoniazid. Reduce the isradipine dose if hypotension or marked edema develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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